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-synuclein, which is a major ingredient of Lewy bodies, in PARK one in 1997 and parkin in PARK two in 1998, which happens to be an E3 ubiquitin ligase and leads to endoplasmic reticulum (ER) anxiety, propose that dysfunction in the intracellular proteinase techniques, including ubiquitin-proteasome technique or lysosomal method, which removes unnec
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